Suppose your application could not be opened when tile is clicked in launchpad, and you observe several failure load of Component-preload.js. You suspect those failure might be the root cause that your application could not be opened?
No, Never.

url for the first preload.js: https://jerry.sap.corp:4080/sap/bc/ui5_ui5/sap/extcrm_opp/_{764EE22A1AF02C826F4F2BF51185C668}5/Component-preload.js
second: https://jerry.sap.corp:4080/sap/bc/ui5_ui5/sap/crm_opprtnty/_{49653C573CF035C44917750591905CDE}5/Component-preload.js
third: https://jerry.sap.corp:4080/sap/bc/ui5_ui5/ui2/ushell/resources/_{20160518082000}/sap/ca/scfld/md/Component-preload.js
By default UI5 framework will always try to load preload.js first:

Even if it fails, the default uncompressed component.js will be loaded as fallback:

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