- central nervous system (CNS)
- peripheral nervous system (PNS)
- enteric nervous system (ENS)
做这部分的科研必须要把这个问题搞得一清二楚，当前到底研究到什么地步了？
从胚胎发育的起源到成熟个体大脑中各种subtype的细胞类型的作用。
分清两个发育过程：
- 生命发育，就是个体的其他器官的发育
- 智能发育，特指神经系统地发育
The single-cell transcriptional landscape of mammalian organogenesis - introduction
- The implantation of the blastocyst on embryonic day (E) 4.0 is followed by gastrulation and the formation of germ layers on E6.5–E7.51,2 .
- At the early-somite stages, the embryo transits from gastrulation to early organogenesis, forming the neural plate and heart tube (E8.0–E8.5).
- In the ensuing days (E9.5–E13.5), the embryo expands from hundreds-of-thousands to over ten million cells, and concurrently develops nearly all major organ systems.
- Unsurprisingly, these four days have been intensively studied. Indeed, most genes that underlie major developmental defects can be studied in this window3,4.
首先，看一下成熟的人和老鼠体内的神经系统是什么样的；
Nervous System - 粗略大概
Nervous System - 3D
其次，每部分的神经系统里面各有哪些subtype的神经细胞；
Neuronal subtype specification in the cerebral cortex
Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain
Neuronal subtype specification in establishing mammalian neocortical circuits
最后，这些神经细胞是如何一步一步从受精卵发育而来的；
这就是我要做的工作
Development of the Nervous System - 在线阅读，看书是学习最快的方法
另附一门课程：Medical Neuroscience
相关数据库：
Molecular Architecture of the Mouse Nervous System - p19-p23, 8w
The single-cell transcriptional landscape of mammalian organogenesis - 部分数据可用
待续~