public static T GetInstance<T>(ExplicitArguments args);

        //

        // Summary:

        //     Creates a new instance of the requested type T using the supplied Instance.

        //     Mostly used internally

        //

        // Parameters:

        //   instance:

        public static T GetInstance<T>(Instance instance);

        //

        // Summary:

        //     Creates or finds the default instance of the pluginType

        //

        // Parameters:

        //   pluginType:

        public static object GetInstance(Type pluginType);

        //

        // Summary:

        //     Creates a new instance of the requested type using the supplied Instance.

        //     Mostly used internally

        //

        // Parameters:

        //   targetType:

        //

        //   instance:

        public static object GetInstance(Type targetType, Instance instance);

var d1 = Type.GetType("GenericTest.TaskA`1"); // GenericTest was my namespace, add yours

Type[] typeArgs = { typeof(Item) };

var makeme = d1.MakeGenericType(typeArgs);

object o = Activator.CreateInstance(makeme);