The pLI score reflects the tolerance of a given gene to the loss of function on the basis of the number of protein truncating variants, that is, the frameshift, splice donor, splice acceptor, and stop-gain variants referenced for this gene in control databases weighted by the size of the gene and the sequencing coverage.

 

It is frequently used to prioritize candidate genes when analyzing whole exome or whole genome data.

 

参考：

A snapshot of some pLI score pitfalls