>>> letters = ['a', 'b', 'c', 'd', 'e', 'f', 'g']

>>> letters

['a', 'b', 'c', 'd', 'e', 'f', 'g']

>>> # replace some values

>>> letters[:] = ['C', 'D', 'E']

>>> letters

['a', 'b', 'C', 'D', 'E', 'f', 'g']

>>> # now remove them

>>> letters[:] = []

>>> letters

['a', 'b', 'f', 'g']

>>> # clear the list by replacing all the elements with an empty list

>>> letters[:] = []

>>> letters

[]