enhancer 和 promoter 组蛋白染色质修饰

  • enhancer:H3K4me1、H3K27ac
  • promoter: H3K4me3、H3K9ac

启动子上的染色质修饰通常无细胞特异性;而增强子的染色质修饰有细胞特异性

enhancer 和 promoter 组蛋白染色质修饰

  • a, We performed k-means clustering on the chromatin modifications found ±5?kb from 414 promoters, and observe them to be generally invariant across cell types. b, As in a, but clustering on 1,423 non-redundant enhancers predicted on the basis of chromatin signatures, revealing the cell-type-specificity of enhancers.

增强子的染色质修饰与细胞类型特异性基因表达全局相关

enhancer 和 promoter 组蛋白染色质修饰

图片来源:Heintzman N D, Hon G C, Hawkins R D, et al. Histone modifications at human enhancers reflect global cell-type-specific gene expression[J]. Nature, 2009, 459(7243): 108-112.

enhancer 和 promoter 组蛋白染色质修饰

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