No matter how resourceful you are, you can't fight fate.

人纵有万般能耐，终也敌不过天命。

I find that I gradually become a fatalist, because I feel that I have little control over my life.

Many times I feel that no matter what I do, there is little change in the consequence.

I was told that the best thing to combat fear, despair and fatalism was knowledge, however, it seems what I have learned from books are totally useless.

Can I change my fate?

Just do the best you can, no one can do more than that.

唯有竭尽全力，此外别无他法。

Compared with the sentence above, that may be the best answer of the question "Can I change my fate?"

Yes, please do the best you can.