修改正负链用到的参数为--flip
假定trial.bim的内容如下:
trial.bim
1 rs142578063 0 732746 G A
1 rs144022023 0 732801 G A
1 rs12131618 0 732809 C T
1 rs369225293 0 732909 A G
1 rs373491075 0 732935 C G
1 rs369030935 0 732989 T C
1 rs4951860 0 733013 C T
1 rs367917297 0 733429 T G
1 rs376492866 0 733895 G A
现在要把修改rs142578063、rs367917297这两个位点的正负链;即rs142578063的G变为C, A变为T,rs367917297的T 变为A, G变为 C, 则需要用到以下命令/software/plink --bfile trial --flip test.missnp --make-bed --out test
其中,test.missnp的内容如下:
test.missnp
rs142578063
rs367917297
修改后的结果如下:
test.bim
1 rs142578063 0 732746 C T
1 rs144022023 0 732801 G A
1 rs12131618 0 732809 C T
1 rs369225293 0 732909 A G
1 rs373491075 0 732935 C G
1 rs369030935 0 732989 T C
1 rs4951860 0 733013 C T
1 rs367917297 0 733429 A C
1 rs376492866 0 733895 G A