import tkinter as tk

def btn1_change_btn1(event):

    '''方式一：通过事件控制自己'''

    if event.widget['state'] == 'normal':

        event.widget['state'] = 'disabled'

    elif event.widget['state'] == 'disabled':

        #event.widget['state'] = 'normal'

        pass

def btn2_change_btn1():

    '''方式二：直接点名，控制别的按钮'''

    if btn1['state'] == 'normal':

        btn1['state'] = 'disabled'

    elif btn1['state'] == 'disabled':

        btn1['state'] = 'normal'

root = tk.Tk()

btn1 = tk.Button(root, text='REOOT', fg="blue", state=tk.DISABLED, width=12, height=1)

btn1.pack()

btn2 = tk.Button(root, text='TEST', fg="blue", state='normal', width=12, height=1, command=btn2_change_btn1)

btn2.pack()

btn1.bind('<Button-1>', btn1_change_btn1)

root.mainloop()