利用win32com处理excle，这样可以不管文件是老的xls还是新的xlsx格式，非常方便。

类的源码如下：

import win32com.client as win32


class easyExcel:

    #初始化读取文件的部分
    def __init__(self, filename=None):
        self.xlApp = win32.Dispatch('Excel.Application')
        self.xlApp.Visible = False
        self.xlApp.DisplayAlerts = False
        if filename:
            self.filename = filename
            self.xlBook = self.xlApp.Workbooks.Open(filename)
        else:
            self.xlBook = self.xlApp.Workbooks.Add()
            self.filename = ''

    #获取sheet的名字，以列表返回
    def getSheetsName(self):
        sheetList = []
        sheetCount = self.xlApp.Worksheets.Count;
        print(sheetCount)
        for i in range(1,sheetCount+1):
            sheetList.append(self.xlBook.Sheets(i).Name)
        return sheetList

    #获取某个sheet的最大行数
    def getMaxRows(self, sheet):
        sht = self.xlBook.Worksheets(sheet)
        return sht.UsedRange.Rows.Count

    #获取某个sheet的最大列数
    def getMaxCols(self, sheet):
        sht = self.xlBook.Worksheets(sheet)
        return sht.UsedRange.Columns.Count

    #获取某个sheet的某行某列的数据，行列全是数字，从1开始
    def getCell(self, sheet, row, col):
        "Get value of one cell"
        sht = self.xlBook.Worksheets(sheet)
        return sht.Cells(row, col).Value
    #修改某个单元格的值
    def setCell(self, sheet, row, col, value):
        "set value of one cell"
        sht = self.xlBook.Worksheets(sheet)
        sht.Cells(row, col).Value = value

    def getRange(self, sheet, row1, col1, row2, col2):
        "return a 2d array (i.e. tuple of tuples)"
        sht = self.xlBook.Worksheets(sheet)
        return sht.Range(sht.Cells(row1, col1), sht.Cells(row2, col2)).Value

    def setRange(self, sheet, leftCol, topRow, data):
        """insert a 2d array starting at given location.
        Works out the size needed for itself"""

        bottomRow = topRow + len(data) - 1
        rightCol = leftCol + len(data[0]) - 1
        sht = self.xlBook.Worksheets(sheet)
        sht.Range(
            sht.Cells(topRow, leftCol),
            sht.Cells(bottomRow, rightCol)
            ).Value = data

    def getContiguousRange(self, sheet, row, col):
        """Tracks down and across from top left cell until it
        encounters blank cells; returns the non-blank range.
        Looks at first row and column; blanks at bottom or right
        are OK and return None witin the array"""

        sht = self.xlBook.Worksheets(sheet)

        # find the bottom row
        bottom = row
        while sht.Cells(bottom + 1, col).Value not in [None, '']:
            bottom = bottom + 1

        # right column
        right = col
        while sht.Cells(row, right + 1).Value not in [None, '']:
            right = right + 1

        return sht.Range(sht.Cells(row, col), sht.Cells(bottom, right)).Value

    #删除某行 或者删除第几行到第几行 1   '1:3'   or  'A:C'
    def deleteRows(self, sheet, row_num):
        sht = self.xlBook.Worksheets(sheet)
        sht.Rows(row_num).Delete()

    #删除某列 或者删除第几列到第几列 1   '1:3'   or  'A:C'
    def deleteRows(self, sheet, col_num):
        sht = self.xlBook.Worksheets(sheet)
        sht.Columns(col_num).Delete()

    def save(self, newfilename=None):
        if newfilename:
            self.filename = newfilename
            self.xlBook.SaveAs(newfilename)
        else:
            self.xlBook.Save()

    def close(self):
        self.xlBook.Close(SaveChanges=0)
        del self.xlApp

2、使用方法

#从写好的类导入方法
from doExcel import easyExcel

#读取excle
excel = easyExcel(r'D:\code\transExcle\testdata\test.xlsx')


#获取Sheet1  第9行2列内的数据
print(excel.getCell('Sheet1', 9, 2))



#修改数据
excel.setCell('Sheet1',9,2,"newdata")

#保存文件
excel.save(r'D:\code\transExcle\testdata\out.xlsx')

#关闭文件
excel.close()

其他方法请自行看源码（第一段代码）可以完美的处理excle的数据